- Jul 07, 2011 · The HSV-1 and HSV-2 IgG kit utilises type-specific proteins to simultaneously detect and differentiate IgG class antibodies to the two most common herpes subtypes, HSV-1 and HSV-2. Dr.T.V.Rao MD 103 104. False Positive Serological Tests1. Cross reacting antibody2.
- Nov 07, 2016 · Agreement was 97.8% for the HSV-2 low positive target, 92.2% for the HSV-2 high negative target, and 32.2% for the HSV-1 high negative target. Carryover and cross-contamination for the ARIES® HSV 1&2 Assay were assessed by testing 15 high positive HSV-1 samples, 15 high positive HSV-2 samples, and 30 HSV-negative samples (Copan UTM).
- Based on an HSV-2 infection prevalence of 15%, the positive predictive value of HerpeSelect may be as low as 50%. The American Academy of Family Physicians, the American College of Obstetricians and Gynecologists (ACOG), and the CDC do not recommend routine serologic screening for genital HSV infection in asymptomatic adolescents or adults because of the large number of false positive results and the lack of a widely available confirmatory test.
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- Example from a Local Lab: Test Includes: Detection of antibodies specific to herpes type 2 only Specimen: Serum\Reference Interval: Negative: 0.91 index Use: Detect IgG antibodies specific to HSV type 2 infection; confirm or rule out possible infection with herpes simplex type 2 virus in prenatal patients in whom HSV 2 infection can cause serious prenatal disease.
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Herpes simplex virus 2 was detected from the CSF in 10 patients, and HSV-1 in 1 patient. In 6 of these 11 patients, the HSV PCR result was positive in more than one disease episode. A significant increase of serum antibodies for HSV was seen in only 1 of 15 episodes examined. Determination of anti-HSV-1 or anti-HSV-2 IgG avidity may also allow the differentiation between primary and recurrent HSV-1 or HSV-2 infections, but there is only very limited experience in this including the diagnosis of genital herpes. 57 Intrathecal HSV antibodies may be of value for the retrospective laboratory diagnosis of CNS infections ... She did not know the false positive rate but explained most people are asymtomatic but that when it is dormant people shed virus. i tested positive for HSV 2 Igg antibody test. During the test I've gotten a yeast infection from my previous high dose of antibiotics. the test came back positivethe IgG test misses 30% of HSV 1 infections and ... a very high rate of false positive results? and the CDC says to never use it to diagnose herpes? Learn More. Based on an HSV-2 infection prevalence of 15%, the positive predictive value of HerpeSelect may be as low as 50%. The American Academy of Family Physicians, the American College of Obstetricians and Gynecologists (ACOG), and the CDC do not recommend routine serologic screening for genital HSV infection in asymptomatic adolescents or adults because of the large number of false positive results and the lack of a widely available confirmatory test. As part of the inhibition assay, sera are re-tested in the routine HerpesSelect HSV-2 IgG ELISA (ie, an aliquot of the sample is diluted in specimen diluent rather than HSV-1 lysate or HSV-2 lysate); the resulting routine ELISA index value is <1.10 for a small percentage of sera. These sera are not considered positive for HSV-2 IgG, and thus the inhibition data can not be interpreted. Herpes is a common STD caused by the herpes simplex virus. Herpes testing diagnoses an active infection when you have a blister, or can tell if you have been infected in the past. HSV-2 is the type most often spread during sex, but HSV-1 may also infect the genital area during oral sex.
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